COUMAPHOS (ICSC)

COUMAPHOS	ICSC: 0422

Date of peer-review: October 1997

O-3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate
Phosphorothioic acid O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester
O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate
O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate

CAS #

56-72-4

C₁₄H₁₆ClO₅PS

RTECS #

GN6300000

Molecular mass: 362.78

UN #

3027

EC #

015-038-00-3

TYPES OF HAZARD / EXPOSURE	ACUTE HAZARDS / SYMPTOMS	PREVENTION	FIRST AID / FIRE FIGHTING
FIRE	Not combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.		In case of fire in the surroundings: powder, water spray, foam, carbon dioxide.
EXPLOSION

EXPOSURE		PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!	IN ALL CASES CONSULT A DOCTOR!
Inhalation	Convulsions. Dizziness. Sweating. Laboured breathing. Nausea. Unconsciousness. Pupillary constriction, muscle cramp, excessive salivation. Symptoms may be delayed (see Notes).	Local exhaust or breathing protection.	Fresh air, rest. Artificial respiration if indicated. Refer for medical attention.
Skin	MAY BE ABSORBED! (Further see Inhalation).	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
Eyes		Face shield, or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion	Abdominal cramps. Diarrhoea. Vomiting. (Further see Inhalation).	Do not eat, drink, or smoke during work.	Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention.

SPILLAGE DISPOSAL

PACKAGING & LABELLING

Evacuate danger area! Do NOT wash away into sewer. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: complete protective clothing including self-contained breathing apparatus).

Do not transport with food and feedstuffs. Severe marine pollutant.
EU Classification
Symbol: T+, N
R: 21-28-50/53
S: (1/2-)28-36/37-45-60-61
UN Classification
UN Hazard Class: 6.1

EMERGENCY RESPONSE

STORAGE

Transport Emergency Card: TEC (R)-61G41a

Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room.

IPCS
International
Programme on
Chemical Safety

Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities © IPCS, CEC 2001

SEE IMPORTANT INFORMATION ON BACK

COUMAPHOS

ICSC: 0422

IMPORTANT DATA

PHYSICAL STATE; APPEARANCE:
COLOURLESS CRYSTALS, WITH CHARACTERISTIC ODOUR.

CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes including sulfur oxides, phosphorous oxides and hydrogen chloride. Reacts slowly with bases to be hydrolyzed.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.

ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:
Cholinesterase inhibitor. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.

PHYSICAL PROPERTIES

Melting point: 91°C
Density: 1.47 g/cm^3
Solubility in water: none
Vapour pressure, Pa at 20°C: 0.000013

Octanol/water partition coefficient as log Pow: 4.13

ENVIRONMENTAL DATA

The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment; special attention should be given to fish, crustacea, birds and mammals. In the food chain important to humans, bioaccumulation takes place, specifically in fish. Avoid release to the environment in circumstances different to normal use.

NOTES

Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Carrier solvents used in commercial formulations may change physical and toxicological properties. Asuntol, Co-ral, Meldane, Muscatox, Perizin, Resitox, Negashunt are trade names.

ADDITIONAL INFORMATION

LEGAL NOTICE

Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information

    See Also:
       Toxicological Abbreviations
       Coumaphos (FAO/PL:1968/M/9/1)
       Coumaphos (WHO Pesticide Residues Series 2)
       Coumaphos (WHO Pesticide Residues Series 5)
       Coumaphos (Pesticide residues in food: 1978 evaluations)
       Coumaphos (Pesticide residues in food: 1980 evaluations)
       Coumaphos (Pesticide residues in food: 1983 evaluations)
       Coumaphos (Pesticide residues in food: 1990 evaluations Toxicology)