International Chemical Safety Cards ACETIC ANHYDRIDE ICSC: 0209 ACETIC ANHYDRIDE Acetic acid, anhydride Acetic oxide Ethanoic anhydride Acetyl oxide C4H6O3/(CH3CO)2O Molecular mass: 102.1 CAS # 108-24-7 RTECS # AK1925000 ICSC # 0209 UN # 1715 EC # 607-008-00-9 TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames, NO sparks, and NO smoking. Alcohol-resistant foam, powder, carbon dioxide (see Notes). EXPLOSION Above 49°C explosive vapour/air mixtures may be formed. Above 49°C use a closed system, ventilation, and explosion-proof electrical equipment. In case of fire: cool drums, etc., by spraying with water but avoid contact of the substance with water. EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR! INHALATION Corrosive. Cough. Laboured breathing. Shortness of breath. Sore throat. Symptoms may be delayed (see Notes). Ventilation, local exhaust, or breathing protection. Fresh air, rest. Half-upright position. Artificial respiration if indicated. Refer for medical attention. SKIN Corrosive. Redness. Pain. Blisters. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention. EYES Corrosive. Redness. Pain. Severe deep burns. Face shield or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION Corrosive. Abdominal pain. Sore throat. Collapse. Do not eat, drink, or smoke during work. Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Consult an expert! Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT absorb in saw-dust or other combustible absorbents (extra personal protection: self-contained breathing apparatus). Fireproof. Separated from food and feedstuffs, incompatible substances (see Chemical Dangers). Dry. Airtight. Do not transport with food and feedstuffs. C symbol R: 10-34 S: (1/2-)26-45 UN Hazard Class: 8 UN Subsidiary Risks: 3 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 0209 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993 No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and IDLH values.

International Chemical Safety Cards ACETIC ANHYDRIDE ICSC: 0209 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS, VERY MOBILE LIQUID , WITH PUNGENT ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic fumes and gases including acetic acid. Reacts violently with boiling water, steam, strong oxidants, alcohols, amines, strong bases, and many other compounds. Attacks many metals in presence of water. The liquid is very corrosive, especially in presence of water or moisture (further see Notes). OCCUPATIONAL EXPOSURE LIMITS (OELs): TLV: 5 ppm; 21 mg/m3 (as TWA) (ACGIH 1993-1994). OSHA PEL: TWA 5 ppm (20 mg/m3) NIOSH REL: C 5 ppm (20 mg/m3) NIOSH IDLH: 200 ppm ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour. INHALATION RISK: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: Corrosive. Tear drawing. The substance is corrosive to the eyes, the skin and the respiratory tract. Inhalation of the vapour may cause lung oedema (see Notes). The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact with skin may cause dermatitis. PHYSICAL PROPERTIES Boiling point: 139°C Melting point: -73°C Relative density (water = 1): 1.08 Solubility in water: Reaction Vapour pressure, kPa at 20°C: 0.5 Relative vapour density (air = 1): 3.5 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01 Flash point: 49°C c.c. Auto-ignition temperature: 316°C Explosive limits, vol% in air: 2.7-10.3 ENVIRONMENTAL DATA N O T E S Forms acetic acid when mixed with water. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered. Major fires must be extingushed with large amounts of water from a distance. Transport Emergency Card: TEC (R)-63 NFPA Code: H 2; F 2; R 1; W ADDITIONAL INFORMATION ICSC: 0209 ACETIC ANHYDRIDE © IPCS, CEC, 1993

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and IDLH values.